LEARNING WITHIN. PREDICTING BEYOND.
One cell line.Can we go beyond?
What we learn from perturbations in one cell line
does not always transfer to a different cellular context.
Observed responses→New context→Responses to predict
↓Explore prediction across contextsSCROLL TO EXPLORE
02 / CONTEXT SHAPES RESPONSE
Context shapesthe response.
The same genetic perturbation can produce different
responses in different cellular contexts.
Understanding the context helps explain the response.
RPE1 · HepG2 · JurkatSource perturbation contexts↗K562Target control context
Four populations illustrate how knowledge transfers across contexts.
03 / CONNECTED BY BIOLOGY
Biology bridgescontexts.
Gene function, pathways, protein interactions and regulation
form shared representations of perturbed genes.
Together with cellular context, they condition diverse responses.
Multiple sources. A shared biological representation.
04 / A POPULATION OF POSSIBILITIES
More thanan average.
Anchored to control cells from the target context,
conditional latent diffusion samples diverse responses,
preserving variation alongside shared changes.
Shared changes. Individual responses.HETEROGENEOUS CELL POPULATIONS
05 / FROM ONE TO A UNIVERSE
Every cell.Its own response.
From one cellular context to a wider perturbation space.
Making cellular diversity visible.